Learn on Demand
Protein Metabolism in Critical Illness
Presenter: Robert Wolfe, PhD
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Knowledge Gap: 
The purpose of this activity is to educate healthcare providers with the most up-to-date information on 
Protein Metabolism in Critical Illness. 

Target Audience
The target audience includes all healthcare professionals such as physicians, nurses, pharmacists and allied health professionals who would like to learn about 
Protein Metabolism in Critical Illness and how it pertains to their respective profession.

Release and Expiration Dates
3/26/2018 -3/26/2021


1. Describe the importance of the hypermetabolic response.
2. Understand the role of protein breakdown in the catabolic response.
3. Understand the role of altered amino acid transport in anabolic resistance.


1.  Wolfe RR. The 2017 Sir David P Cuthbertson lecture. Amino acids and muscle protein metabolism in critical care. Clin Nutr. 2017 Dec 21. pii: S0261-5614(17)31430-9.doi10.1016/j.clnu.2017.12.010.
2.  Pencharz PG, Elango R, Wolfe RR. Recent developments in understanding protein needs - How much and what kind should we eat? Appl Physiol Nutr Metab 41(5):577-80, 2016.
3.  Wolfe RR. The underappreciated role of muscle in health and disease. Am J Clin Nutr 84(3):475-482, 2006.
4.  Wolfe, RR. Protein metabolism in critical illness: assessment and nutritional implications. Amino acid and protein metabolism in health and disesase: Nutritional implications. Paolo, T, PB Soeters, G Pitoni, A Tiengo, eds. Smith-Gordon, London: pp 117-123, 1998.

Biographical Info

Robert R. Wolfe, Ph.D

Dr. Robert R. Wolfe’s undergraduate studies were at the University of California, Berkeley, and he completed his Ph.D. degree at UC Santa Barbara’s Institute of Environmental Stress. Dr. Wolfe served as a faculty member at Harvard Medical School for nine years. Prior to accepting his current position in 2006, he was at the UT Medical Branch at Galveston, where he held the John H. Sealy Distinguished Chair in Clinical Research and was Chief of the Metabolism Unit at Shriners Burns Hospital. Dr. Wolfe has received a number of awards and invited lectureships in recognition of his work. He received the Herman Award from the American Society of Clinical Nutrition for his career contributions. He has published over 452 peer-reviewed research articles, 126 review articles, three books, including the major reference source in the field of stable isotope tracer methodology and has 5 patents. His papers have been cited 50,663 times (h index= 122), and 16,423 (h index =65) since 2011. Dr. Wolfe has been funded continuously by the NIH for his entire career and frequently held two NIH grants per year as Pl.

The focus of Dr. Wolfe’s research is on the regulation of muscle metabolism, particularly as affected by aging and stressors such as injury, sepsis and cancer. His research has been performed largely in human patients and normal volunteers. Dr. Wolfe has developed models using stable isotopes to quantify a variety of metabolic processes in human subjects including the oxidation and production of fatty acids, various aspects of carbohydrate metabolism, and the rates of muscle protein synthesis, breakdown, and the transport of amino acids between blood and muscle tissue. Dr. Wolfe is the Director of the Center for Translational Research in Aging and Longevity at the Reynolds Institute on Aging.

Speaker Disclosures:
The planners, speakers, moderators, peer reviewers and /or panelists of this CE activity have no relevant financial relationships with commercial interests to disclose.

The following planner, speaker, moderator, and/or panelist of this CE activity has financial relationships with commercial interests to disclose:

Robert R. Wolfe, Ph.D 
  • Co-owner of Essentail Blends, LLC
  • Consultant - Accella, LLC
  • Consultant - Trivita, LLC
  • Consultant and Grant/Research Support - National Cattleman's Beef Association
  • Consultant and Grant/Research Support - Abbott Nutrition

A review of the disclosed financial relationships and the assignment revealed that no conflict of interest exists.

Priya Mendiratta, MD
Paula Podrazik, MD
Gohar Azhar, MD
Susan Smithwick, MD

Robert R. Wolfe, Ph.D

Peer Reviewers: 
Kim Miller, MCHES

Instructions to obtain credit:

1.       Launch the activity 
2.       View the entire activity online 
3.       Complete the post-test 
           (must pass the post-test with a score of 65% to receive credit)
           You may retake the post-test if you do not receive a passing score.
4.       Complete Evaluation 
Print certificate or transcript (Available in the “My Profile” tab).

Direct Provider Statement
In support of improving patient care, University of Arkansas for Medical Sciences is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

Designation Statement 
The University of Arkansas for Medical Science Office of Continuing Education designates this live activity for a maximum of 1.00 AMA PRA Category 1 CreditsTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Disclosure Policy statement

It is the policy of the University of Arkansas for Medical Sciences Office of Continuing Education to ensure balance, independence, objectivity and scientific rigor in all provided and jointly provided educational activities.  All individuals who are in a position to control the content of the educational activity (course/activity, directors, planning committee members, staff, teachers, or authors of CE) must disclose all relevant financial relationships they have with any commercial interest(s) as well as the nature of the relationship.  Financial relationships of immediate family members must also be disclosed, if the nature of the relationship(s) could influence the objectivity of the individual in a position to control the content.  The ACCME describes relevant financial relationships as those in any amount occurring within the past 12 months that create a conflict of interest.  Individuals who refuse to disclose are disqualified from participation in the development, management, presentation, or evaluation of the CE activity.

UAMS Office of Continuing Education

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Little Rock, AR 72205
Phone: 501-661-7962 Fax: 501-661-7968

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Type:  Internet Activity (Enduring Material)
14 Registered Users
1 Hours> Non-Accredited

1 Credits> Accreditation Council for Continuing Medical Education> AMA PRA Category 1 Credit