Learn on Demand

Learn on Demand

Common Medications in Sickle Cell Disease
Presenter: Lindsey Dayer, PharmD, BCACP
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Knowledge Gap: 
The purpose of this activity is to educate healthcare providers with the most up-to-date information on Common Medications in Sickle Cell Disease.  

Target Audience
The target audience includes all healthcare professionals such as physicians, nurses, pharmacists and allied health professionals who would like to learn about Common Medications in Sickle Cell Disease and how it pertains to their respective profession.

Release and Expiration Dates
6/12/2018 -6/12/2021
Objectives
  1. Explain the pathophysiology of sickle cell disease (SCD)
  2. Recommend appropriate immunization schedule for non-routine vaccinations 
  3. Discuss medications used for SCD and their purpose
References:
  1. FDA Briefing Document. Oncologic Drugs Advisory Committee Meeting. NDA 208587 L-glutamine. FDA US Food & Drug Administration. https://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials
  2. /Drugs/OncologicDrugsAdvisoryCommittee/UCM559734.pdf Accessed 5/31/18.
  3. Yawn BP, Buchanan GR, Afenyi-Annan AN, et al. Management of Sickle Cell Disease Summary of the 2014 Evidence-Based Report. Clinical Review & Education. Special Communication. JAMA. 2014;312(10):1033-1048. doi:10.1001/jama.2014.10517
  4. Rees DC, Williams TN, Gladwin M. Sickle-cell disease. Lancet 2010;376:2018-31
  5. Bunn HF. “Pathogenesis and Treatment of Sickle Cell Anemia” N Engl J Med 1997; 337:762-769
  6. Osunkwo I, Hodgman EI, Cherry K, et al. Vitamin D deficiency and chronic pain in sickle cell disease. British Journal of Haematology. 2011;153:529-540
  7. JB Herrick. Peculiar elongated and sickle-shaped red blood corpuscles in a case of severe anemia. Arch Intern Med 6(1910).pp.517-521
  8. Estepp JH. Voxelotor (GBT440), a first-in-class hemoglobin oxygen-affinity modulator, has promising and reassuring preclinical and clinical data. Am J Hematol. 2018;93:326–329. https://doi.org/10.1002/ajh.25042 
  9. Charache S, Terrin ML, Moore RD et al. Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the Multicenter Studiy of Hydroxyurea in Sickle Cell Anemia. N Engl J Med. 1995;332(20):1317-22
  10. Thompson BW, Miller ST, Rogers ZR, et al. The pediatric hydroxyurea phase III clinical trial (BABY HUG): Challenges of study design. Pediatr Blood Cancer. 2010;54(2):250-255
  11. CDC Immunization Schedules. Centers for Disease Control and Prevention. Accessed at https://www.cdc.gov/vaccines/schedules/index.html. Accessed on June 8, 2018

Biographical Info

Lindsey Dayer, PharmD, BCACP
Assistant Professor, Director of Experiential Education

Bachelor of Science in Biology, University of the Ozarks, Clarksville, Arkansas, 2001-2005
Doctor of Pharmacy, University of Arkansas for Medical Sciences College of Pharmacy, Little Rock, Arkansas, 2005-2009
Pharmacy Practice Residency, University of Arkansas for Medical Sciences, Little Rock, Arkansas, 2009-2010

Speaker Disclosures:
The planners, speakers, moderators, peer reviewers and /or panelists of this CE activity have no relevant financial relationships with commercial interests to disclose.

Planners: 
Kim Miller  
Susan Smith Dodson

Speaker:
Lindsey Dayer, PharmD, BCACP

Peer Reviewers: 
Kim Miller, MCHES

Instructions to obtain credit:

1.       Launch the activity 
2.       View the entire activity online 
3.       Complete the post-test 
           (must pass the post-test with a score of 65% to receive credit). 
           You may retake the post-test if you do not receive a passing score.
4.       Complete Evaluation 
Print certificate or transcript (Available in the “My Profile” tab).

Direct Provider Statement
In support of improving patient care, University of Arkansas for Medical Sciences is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

Designation Statement 
The University of Arkansas for Medical Science Office of Continuing Education designates this live activity for a maximum of 1.00 AMA PRA Category 1 CreditsTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

The University of Arkansas for Medical sciences designates this enduring activity for a maximum of 1.00 ANCC contact hours. Nursing contact hours will be awarded for successful completion of program components based upon documented attendance and completion of evaluation materials.

Disclosure Policy statement

It is the policy of the University of Arkansas for Medical Sciences Office of Continuing Education to ensure balance, independence, objectivity and scientific rigor in all provided and jointly provided educational activities.  All individuals who are in a position to control the content of the educational activity (course/activity, directors, planning committee members, staff, teachers, or authors of CE) must disclose all relevant financial relationships they have with any commercial interest(s) as well as the nature of the relationship.  Financial relationships of immediate family members must also be disclosed, if the nature of the relationship(s) could influence the objectivity of the individual in a position to control the content.  The ACCME describes relevant financial relationships as those in any amount occurring within the past 12 months that create a conflict of interest.  Individuals who refuse to disclose are disqualified from participation in the development, management, presentation, or evaluation of the CE activity.

UAMS Office of Continuing Education

4301 W. Markham #525
Little Rock, AR 72205
Phone: 501-661-7962 Fax: 501-661-7968

Learn On Demand Contact Us:
For information regarding this educational activity or website, please contact

Center for Distance Health
4301 W. Markham #519
Little Rock, AR 72205
Toll Free: 1-855-234-3348
Email: cdheducation@uams.edu


Type:  Internet Activity (Enduring Material)
52 Registered Users
Credits
1 Hours> Non-Accredited
1 Credits> Accreditation Council for Continuing Medical Education> AMA PRA Category 1 Credit™
1 Contact Hours> American Nurses Credentialing Center> ANCC
1 CECH, 1 CECH> National Commission for Health Education Credentialing, Inc. > CHES