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Roles of Protein Aggregation in Age-Progressive Diseases
Presenter: Robert Reis, MD
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Knowledge Gap: 
The purpose of this activity is to educate healthcare providers with the most up-to-date information on 
Roles of Protein Aggregation in Age-Progressive Diseases. 

Target Audience
The target audience includes all healthcare professionals such as physicians, nurses, pharmacists and allied health professionals who would like to learn about 
Roles of Protein Aggregation in Age-Progressive Diseases and how it pertains to their respective profession.

Release and Expiration Dates
04/04/2018 -04/04/2021


1. Understand the roles of aggregates in diverse neurodegenerative disease.
2. Understand the generality of protein aggregation, its age-dependence, and its part in inflammation.
3. Recognize the importance of anti-inflammatory drugs, and the development of novel compounds optimized for anti-aggregation activity.


1. Ayyadevara S, Balasubramaniam MS, Gao Y, Yu L-R, Zybaylov B, Alla R, Shmookler Reis RJ (2015) Proteins in aggregates functionally impact multiple neurodegenerative disease models by forming proteasome-blocking complexes. Aging Cell 14:35-48. PMC4326912. Featured, World Biomed. Frontiers 2015.

1. Ayyadevara S, Balasubramaniam M, Parcon P, Barger SW, Griffin WS, Alla R, Tackett AJ, Mackintosh SG, Petricoin E, Zhou W, Shmookler Reis RJ (2016) Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls. Aging Cell 15:924-939, 2016. PMC5013017.

1. Ayyadevara S, Balasubramaniam M, Johnson J, Alla R, Mackintosh SG, Shmookler Reis RJ (2016) PIP-binding proteins promote age-dependent protein aggregation and limit survival in C. Elegans. Oncotarget 7:48870-48886. Cover article; selected as a Priority Research Paper. DOI: 10.18632/oncotarget.10549

Biographical Info

Robert J. S. Reis, D.Phil

Robert J.S. Reis, D.Phil holds a BA from Harvard University (B.A.) and D. Phil from Sussex University, U.K. at UAMS, he holds the Udupa Chair in Gerontology Research, aand at the VAMC he is a Senior Research Career Scientist. The Reis lab has focused for several years on protein aggregation as a unifying feature of many or all age-progressive diseases and on specific aggregate proteins that appear to play functional roles in the formation or clearance of aggregates.

Speaker Disclosures:
The planners, speakers, moderators, peer reviewers and /or panelists of this CE activity have no relevant financial relationships with commercial interests to disclose.

Priya Mendiratta, MD
Paula Podrazik, MD
Gohar Azhar, MD
Susan Smithwick, MD

Lisa C Hutchison, PharmD, MPH

Peer Reviewers: 
Kim Miller, MCHES

Instructions to obtain credit:

1.       Launch the activity 
2.       View the entire activity online 
3.       Complete the post-test 
           (must pass the post-test with a score of 65% to receive credit)
           You may retake the post-test if you do not receive a passing score.
4.       Complete Evaluation 
Print certificate or transcript (Available in the “My Profile” tab).

Direct Provider Statement
In support of improving patient care, University of Arkansas for Medical Sciences is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

Designation Statement 
The University of Arkansas for Medical Science Office of Continuing Education designates this live activity for a maximum of 1.00 AMA PRA Category 1 CreditsTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Disclosure Policy statement

It is the policy of the University of Arkansas for Medical Sciences Office of Continuing Education to ensure balance, independence, objectivity and scientific rigor in all provided and jointly provided educational activities.  All individuals who are in a position to control the content of the educational activity (course/activity, directors, planning committee members, staff, teachers, or authors of CE) must disclose all relevant financial relationships they have with any commercial interest(s) as well as the nature of the relationship.  Financial relationships of immediate family members must also be disclosed, if the nature of the relationship(s) could influence the objectivity of the individual in a position to control the content.  The ACCME describes relevant financial relationships as those in any amount occurring within the past 12 months that create a conflict of interest.  Individuals who refuse to disclose are disqualified from participation in the development, management, presentation, or evaluation of the CE activity.

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Type:  Internet Activity (Enduring Material)
11 Registered Users
1 Hours> Non-Accredited

1 Credits> Accreditation Council for Continuing Medical Education> AMA PRA Category 1 Credit